PC Bone, 32, and her colleague PC Hughes, 23, suffered fatal injuries in a gun and grenade attack in Mottram, Tameside, on Tuesday.
Mr Cregan, 29, has also been charged with the murders of Mark Short in May and his father David in August.
A second man, Stephen Garvey, 28, was arrested on Wednesday on suspicion of conspiracy to commit murder.
Mr Cregan has also been charged with the attempted murders of Michael Belcher, Ryan Pridding and John Short on 25 May and Sharon Hark on 10 August.
At a news conference Nazir Afzal, Chief Crown Prosecutor for CPS North West, said he had authorised Greater Manchester Police to bring the charges.
"The tragic events this week in which Police Constables Fiona Bone and Nicola Hughes lost their lives in the line of duty have shocked and appalled the whole country," he said.
Police have also charged him with the attempted murders of Michael Belcher, Ryan Pridding and John Short on 25 May and Sharon Hark on 10 August.
Sir Peter Fahy, Chief Constable of Greater Manchester Police, described the inquiry as a "complex investigation".
He renewed police appeals for anyone with information to contact detectives. calling on "those people look at their conscience and come forward".
Mr Cregan is due to appear at Manchester Magistrates' court on Friday.
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